Misoprostol (Cytotec®)

 
Dr Ph. Rault - Adrénaline112.org
Mis en ligne en janvier 2001


Forme et présentation
Comprimé sécable à 200 microgrammes


Indications
- Traitement de l'ulcère gastro-duodénal évolutif
- Traitement des lésions gastroduodénales induites par les anti-inflammatoires non stéroïdiens
- Hémorragie de la délivrance


Pharmacodynamie
Activité antisecrétoire et cytoprotectrice.
Analogue synthétique de la prostaglandine E1 responsable d'une puissante activité sur la contractilité du muscle utérin.


Contre-indications
- hypersensiblité à l'un des constituants
- grossesse


Voici la conclusion de l'article de O'Brien P et coll.
Department of obstetrics and Gynaecology, University College Hospital, London, United Kingdom.
Rectally administrated misoprostol for the treatment of postpartum hemorrhage to oxytocin and ergometrine: a descriptive study.
"Misoprostol appears to be absorbed effectively from rectal as well as oral and vaginal mucosa. Rectally administrated misoprostol appears to be an effective treatment for postpartum hemorrhage unresponsive to oxytocin and ergometrine; therefore, it might be an alternative to parenteral prostaglandins or at least minimize the number of women requiring this invasive treatment. Given that it is an inexpensive and stable drug, misoprostol has considerable potential to reduce maternal mortality from postpartum hemorrhage in developing countires"